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PPROTECTIVE EFFECT OF QUERCETIN ON ACUTE TOXICITY OF SODIUM ARSENITE IN RAT LIVER AND KIDNEY

WATCHARAPORN, DEVAKUL NA AYUTTHAYA.1, NAOVARAT, TARASUB.2, VINIT, JARUPARNITKUL.3, THONGBAI, CHANSEECHA.4, TEERADECH, SURAMANA.1

1 Phramacology and Toxicology Unit, Department of Medical Sciences, Faculty of Health Science and the Health Science Research Center, RSU.
2 Anatomy Unit, Department of Medical Sciences, Faculty of Science, RSU.
3 Biomedical Science Program, Faculty of Science, RSU.
4 Pathobiology Unit, Department of Medical Sciences, Faculty of Science, RSU.


        This study was aimed to determine the effect of quercetin in attenuating the acute toxicity induced by sodium arsenite in rat liver and kidney. Male Wistar rats received either sodium arsenite alone in the dose of 10 and 30 mg/kg and pretreatment with quercetin at dose of 100 mg/kg for 1 hour before they were given sodium arsenite at dose of 30 mg/kg by single oral gavage. The effect of different treatments was studied on two parameters which include the activities of hepatic marker enzymes (ALT and AST) in serum and histoarchitecture of liver and kidney at the light microscopic level. The activities of ALT and AST were decreased following treatment with sodium arsenite 10 and 30 mg/kg to normal rats in dose-dependent manner. However, the activities of ALT and AST were increased in quercetin at dose of 100 mg/kg before treatment with sodium arsenite 30 mg/kg. The activity of AST was increased significantly in this group when compared to arsenite 30 mg/kg treated group. In addition, the result of histopathological study had no significant changes in liver and kidney for all groups of treatment. This study concluded that sodium arsenite could induce hepatotoxicity by decreasing the activities of ALT and AST and quercetin in the dose of 100 mg/kg had the potential in alleviating the toxic effects of sodium arsenite by increasing the activities of ALT and AST. However, this toxicity was not detected by histopathological changes of liver and kidney. The action of quercetin in attenuating the acute hepatotoxicity induced by sodium arsenite may be proposed by deactivating PI3-K and reducing the expression of Bcl-2 gene that function in inhibiting apoptosis.

ที่มา :
การประชุมวิชาการสมาคมพิษวิทยาแห่งประเทศไทย ประจำปี 2548 Food & Chemical Safety วันที่ 17-18 พฤศจิกายน 2548 โรงแรมแกรนด์ ทาวเวอร์อินน์ ถนนพระรามหก กรุงเทพฯ