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EFFECT OF QUERCETIN ON ACUTE HEPATOTOXICITY OF NICKEL CHLORIDE IN RAT

WATCHARAPORN, DEVAKUL NA AYUTTHAYA.1, NAOVARAT, TARASUB.2, ZANZAROT, PHATTHARRATHORN.3, THONGBAI, CHANSEECHA.4, TEERADECH, SURAMANA.1

1 Phramacology and Toxicology Unit, Department of Medical Sciences, Faculty of Health Science and the Health Science Research Center, RSU.
2 Anatomy Unit, Department of Medical Sciences, Faculty of Science, RSU.
3 Biomedical Science Program, Faculty of Science, RSU.
4 Pathobiology Unit, Department of Medical Sciences, Faculty of Science, RSU.

        This study was aimed to determine the effect of quercetin in attenuating the acute hepatotoxicity induced by nickel chloride in rat. Male Wistar rats received either nickel chloride alone in the dose of 50, 150 and 300 mg/kg and pretreatment with various doses of quercetin (50, 100 and 200 mg/kg) for 1 hour before they were given nickel chloride at dose of 300 mg/kg by single oral gavage. The effect of different treatments was studied on two parameters which include the activities of hepatic marker enzymes (ALT and AST) in serum and histoarchitecture at the light microscopic level. The activities of ALT and AST were increased following treatment with nickel chloride to normal rats in dose-dependent manner. However, the activities of ALT and AST were also increased in quercetin at dose of 50 and 100 mg/kg but decreased in quercetin at dose of 200 mg/kg. In addition, the result of enzyme activities was also related to the alterations of hepatic histoarchitecture. Nickel chloride 300 mg/kg treated rats showed the alterations in normal hepatic histoarchitecture which comprise of vacuolization of the hepatocytes and fatty liver. Administration of quercetin 200 mg/kg to nickel chloride treated rats resulted in marked improvement in the structure of hepatocytes, but not shown in the dose of 100 mg/kg quercetin. This study concluded that nickel chloride in the dose of 300 mg/kg could induce hepatotoxicity and quercetin in the dose of 200 mg/kg had the potential in alleviating the toxic effects of nickel chloride. The possible mechanisms of quercetin may involve its property in act as a free radical scavenger, or its indirect action in reducing the level of oxygen reactive species.

ที่มา :
การประชุมวิชาการสมาคมพิษวิทยาแห่งประเทศไทย ประจำปี 2548 Food & Chemical Safety วันที่ 17-18 พฤศจิกายน 2548 โรงแรมแกรนด์ ทาวเวอร์อินน์ ถนนพระรามหก กรุงเทพฯ