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ความรู้ทั่วไปเกี่ยวกับสิ่งเป็นพิษความรู้ทั่วไปที่นักวิชาการควรทราบพิษวิทยาคลีนิคก้าวทันโลกข้อมูลบริการแหล่งข้อมูลที่เกี่ยวข้อง
 
   
PROTECTIVE EFFECT OF QUERCETIN ON CHROMOSOME ABERRATIONS AND SPLEEN TOXICITY INDUCED BY HEXAVALENT CHROMIUM IN RATS

TARASUB, NAOVARAT.1, TARASUB, CHINNAWAT.2, SATITKRENGKRAI, TEERAPAT.3, DEVAKUL NA AYUTTHAYA, WATCHARAPORN.4, SURAMANA, TEERADECH.4

1. Anatomy Unit, Department of Medical Sciences, Faculty of Science, Rangsit University, Pathumthani, Thailand
2. Anatomy Unit, Department of Medical Sciences, Faculty of Medicine, Thammasat University, Pathumthani, Thailand
3. Biomedical Science Program, Faculty of Science, Rangsit University, Pathumthani, Thailand
4. Pharmacology and Toxicology Unit, Department of Medical Sciences, Faculty of Science, Rangsit University, Pathumthani, Thailand.

        Quercetin, one of the major flavonoids in some fruits and vegetables, has much stronger antioxidative and anticarcinogenic activities. This study was planned to investigate the potential protective effects of quercetin in attenuating the acute toxicity induced by hexavalent chromium. Male Wistar rats were administered hexavalent chromium in the form of K2C2O7 at dose of 0, 5, 10 and 20 mg/kg and quercetin at dose of 100 mg/kg for one hour before administration of hexavalent chromium 20 mg/kg. All rats were treated by single oral gavage and killed 24 hours after each treatment. The effects of different treatments were studied on two parameters which include chromosome aberrations and histopathological changes of spleen at the light microscopic level. The results indicated that the morphology of cells in spleen was not changed in all groups of treatment. However, a significantly increase in percentage of chromosome aberrations was observed in hexavalent chromium at dose of 5, 10 and 20 mg/kg as compared the control (23.66 ± 2.33, 39.33 ± 3.52, 63.33 ± 3.52 and 8.66 ± 1.76, respectively, p  < 0.05). This increase of chromosome aberrations was dose-dependent response. Interestingly, the percentage of chromosome aberrations induced by hexavalent chromium 20 mg/kg could be reduced significantly by quercetin pretreatment (63.33 ± 3.52 and 8.66 ± 3.52, respectively, p  < 0.05). Our findings provide evidence that quercetin was able to protect against hexavalent chromium-induced chromosome aberrations in rat bone marrow, which underlie its suggested anticarcinogenic properties. We suggested that quercetin might neutralize free radicals and reduce or even help prevent some of the chromosome damages.

Keywords : quercetin, chromosome aberrations, spleen toxicity, hexavalent chromium

ที่มา :
การประชุมวิชาการสมาคมพิษวิทยาแห่งประเทศไทย ประจำปี 2548 Food & Chemical Safety วันที่ 17-18 พฤศจิกายน 2548 โรงแรมแกรนด์ ทาวเวอร์อินน์ ถนนพระรามหก กรุงเทพฯ