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ความรู้ทั่วไปเกี่ยวกับสิ่งเป็นพิษความรู้ทั่วไปที่นักวิชาการควรทราบพิษวิทยาคลีนิคก้าวทันโลกข้อมูลบริการแหล่งข้อมูลที่เกี่ยวข้อง
 
   
PSYCHOMOTOR PERFORMANCE AND MOOD EVALUATION AFTER CAFFEINE COMSUMPTION

JANTAPASO, JATURONG.1, SUPAVILAI, PORNTIP.2, SRIWATANAKUL, KAMPON.2, YOOVATHAWORN, KRONGTONG.2, WILAIRAT, PRAPIN. 3, CHENTANEZ, THYON.4

1 Toxicology Graduate Programme, Faculty of Science, Mahidol University, Thailand
2 Department of Pharmacology Faculty of Science, Mahidol University, Thailand
3 Department of Chemistry Faculty of Science, Mahidol University, Thailand
4 Department of Physiology Faculty of Science, Mahidol University, Thailand


Abstract
        Methylxanthine, caffeine, is the world’s most popular psychoactive drug. It is popularly consumed in various races and by people of a wide range of age. Caffeine is contained in coffee, tea, soft drinks and chocolate. In Thailand, there are a lot of new caffeine-containing products (e.g. coffee, tea, and green tea) and the marketing competition is very strong. Caffeine consumption tends to be higher each year. The study investigated the effects of 50, 100 and 200 mg caffeine on the psychomotor performance and mood in healthy Thai volunteers. In addition, this study aimed to determine plasma and urinary caffeine and paraxanthine levels after caffeine consumption and to correlate the effects of caffeine on psychomotor performance (simple reaction time) and mood to urinary and plasma caffeine and paraxanthine levels. Thirty healthy volunteers (16 females and 14 males) participated in the study. The study design was a double-blind, crossover, and placebo controlled trial. Simple reaction time, mood evaluation and cardiovascular function were observed before and after drug administration. The results showed that 50 mg caffeine did not cause any effect. There was a dose-response relationship in the psychomotor performance. The study indicated that caffeine at 100 and 200 mg quickened simple reaction time. Peak performance was found within 60-90 min after consumption. Mood assessment revealed that the subjects were more alert and energetic after 100 and 200 mg caffeine consumption from 1 to 3 hours post dose. An increase in blood pressure and decrease in heart rate were observed at 45 to 105 min after drug administration. The adverse effects reported in the study were palpitations (6-20 %), tremors (3-10 %) and nausea (3-6 %) after 100 and 200 mg of caffeine consumption. The levels of caffeine and paraxanthine in plasma and urine were determined by high performance liquid chromatography (HPLC) technique. Peak plasma concentration and highest urinary caffeine levels were observed at 45 and 60 min, respectively. The statistical analysis showed an association between psychomotor performance and urinary caffeine level. The appropriate dose that can improve psychomotor performance and mood without significant adverse effects is around 100 mg; however, dosage should not exceed 200 mg.


KEY WORDS: CAFFEINE/ PSYCHOMOTOR PERFORMANCE/ MOOD/ HPLC

ที่มา : การประชุมวิชาการสมาคมพิษวิทยาแห่งประเทศไทย ประจำปี 2548 Food & Chemical Safety วันที่ 17-18 พฤศจิกายน 2548 โรงแรมแกรนด์ ทาวเวอร์อินน์ ถนนพระรามหก กรุงเทพฯ