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ความรู้ทั่วไปเกี่ยวกับสิ่งเป็นพิษความรู้ทั่วไปที่นักวิชาการควรทราบพิษวิทยาคลีนิคก้าวทันโลกข้อมูลบริการแหล่งข้อมูลที่เกี่ยวข้อง
 
   
EFFECT OF QUERCETIN ON THE CHANGES OF CHROMOSOME AND TESTICULAR HISTOLOGY INDUCED BY SODIUM ARSENITE IN RATS

NAOVARAT TARASUB1, CHINNAVAT TARASUB2,
CHAIWAT THAVAROJANA3, ORNANONG RATTANABANNAKIT4,
THONGBAI JANSEECHA1, DHASANAI SURIYACHAN5,
TEERADECH SURAMANA5

1 Anatomy Unit, Department of Medical Sciences, Faculty of Science, Rangsit University, Pathumthani, Thailand
2 Anatomy Unit, Department of Medical Sciences, Faculty of Medicine, Thammasat University, Pathumthani, Thailand
3 Biomedical Science Program, Faculty of Science, Rangsit University,Pathumthani, Thailand
4Pharmacy Program, Faculty of Pharmacy, Rangsit University, Pathumthani, Thailand
5 Pharmacology and Toxicology Unit, Department of Medical Sciences, Faculty of Science and The Health Science Research Center, Rangsit University, Pathumthani, Thailand.

      Quercetin belongs to a group of plant pigments called flavonoids that are largely responsible for the colors of many fruits, flowers, and vegetables. Quercetin also works as an antioxidant by scavenging damaging particles in the body known as free radicals. The aim of this study is whether the quercetin can inhibit the toxic effects of sodium arsenite. The changes of chromosome and testicular histology were used as indicators of arsenic-induced toxicity. Male Wistar rats were administered sodium arsenite by oral feeding at doses 10, 20 and 30 mg/kg for 24 hours. There was not significant change in testicular histology. The chromosomal aberrations were prominent in rats that were given with arsenite at 30 mg/kg. To evaluate the inhibitory effect on the arsenic-induced toxicity, quercetin was administered by oral feeding before the treatment with sodium arsenite at the 30 mg/kg groups. The quercetin at doses 100 mg/kg can partially inhibit the arsenic-induced toxicity. This study found that quercetin may neutralize free radicals and may reduce or even help prevent some of the damages induced by the sodium arsenite.

ที่มา ABSTRACT นำเสนอที่ การประชุมวิชาการสมาคมพิษวิทยาแห่งประเทศไทย ประจำปี 2547 อาหารกับความปลอดภัย วันศุกร์ที่ 17 ธันวาคม 2547 โรงแรมมิราเคิลแกรนด์ กรุงเทพฯ