*Institute of Medical Plant Researh
**Division of Clinical Pathology, Department of Medical Sciences
Bulletin of Department of Medical Sciences 1998; 40(1): 9-21
Thai with English abstract
Quisqualis indica Linn.
Seed has long been used in folk medicine as an ascaricide. Toxicity studies of the
seed were carried out in mice and rat in order to gain more information on using as
an safety human anthelmentic. Our results revealed that mice receiving water extract
equivalent to the seed at the dose of 20.0 g/kg/day orally showed no acute toxicity
and therefore LD50 was more than 20.0 g/kg/day. The subacute toxicity study in Wistar
rats by administration of water extract equivalent to the seed at the doses of 0.2, 2.0, 6.
0, 10.0 and 20.0 g/kg/day for 60 consecutive days showed that after receiving the
extract equivalent to the seed of 6.0, 10.0 and 20.0 g/kg/day for 2 days, the animals
showed abnormal clinical signs; the notable ones were clonic with tonic seizures
followed by respiratory arrest and death. The percentages of rats presenting toxic
symptoms and death at the doses of 6.0, 10.0 and 20.0 g/kg/day in male were
26, 53 and 80 respectively, and in female were 0, 6 and 80, respectively.
All rats died after receiving the highest dose only for 3 consecutive days.
The growth rate and feed consumption of the survived rats receiving the
extract for 60 days were not different from control group. Hematological and
biochemical alterations of some parameters were observed in some group of
rats receiving the extract but these did not correlate with the increasing doses of
the extract and hence should not be attributable to the toxicity of the Q. indica seed.
Histopathological study of internal organs revealed no remarkable lesions accounted
for the toxicity of the Q. indica seed.